MY RESEARCH INTERESTS lie in the general province of numerical simulation of physical systems. Most recently, my focus has been the study of large biomolecular systems. For example, the image at right depicts an inhibitor molecule bound covalently into the active site of a β-lactamase enzyme. The β-lactamases catalyze the hydrolysis of antibacterial agents such as penicillin and cephalosporin and play a large role in bacterial resistance to antibiotics. My research has pointed to a novel, substrate-catalyzed mechanism of action in the class A and class C enzymes.